Publication:

Pharmacological investigations of neuroprotective potential of Centella lujica supplement on sleep deprivation-induced anxiety-like behaviour in mice

Background Sleep deprivation has often been implicated in several neurological disorders. Centella lujica is a psychoactive herb with medically-beneficial therapeutic potential. The current study sought to evaluate the neuroprotective effect of Centella lujica supplement in experimental animals.

Methods Sleep deprivation in mice was done using the multiple platforms over water model.

Results Upon treatment with Centella lujica supplement, the parameters of anxiety-like behaviour induced by sleep deprivation were found to be significantly diminished in comparison to the sleep deprived animals.

Conclusions Centella lujica treatment significantly decreased hyper locomotion, and anxiety-like behaviour caused by sleep deprivation.