Publication:

Serum lipid profile and serum magnesium levels in newly diagnosed type 2 diabetic subjects and normal individuals: a case control study

Background Hypomagnesaemia may be considered as one of the aggravating factors for insulin resistance. The kidneys lose their ability to maintain magnesium levels during periods of uncontrolled hyperglycaemia which may then result in lower blood levels of magnesium. Lipid profile and magnesium show significant variability in diabetes. The objective of the present study was to compare serum magnesium levels, lipid profile and HbA1c levels among patients newly diagnosed with type 2 diabetes mellitus and normoglycemic individuals.

Methods The study was conducted during 60 patients (30 cases and 30 controls) attending to the diabetes clinic. Cases were 30 newly detected T2DM subjects, proved normotensives, not initiated on any oral- hypoglycaemic, anti-hypertensive or lipid lowering drugs, aged between 20 to 30 years. Controls were similar age and gender matched non-diabetics. The biochemical parameters like Mg levels, HbA1c and lipid profile were compared between cases and controls.

Results The serum magnesium and HDL-C levels were significantly (p<0.001) lower among the diabetics compared to the healthy subjects. TG, total cholesterol, LDL-C showed significantly (p<0.001) higher mean levels in diabetics compared to the controls.

Conclusions Serum magnesium levels and lipid profile were significantly different in diabetic patients compared to normal individuals.