Publication:

Cardiometabolic index as a predictor of left ventricular remodeling post myocardial infarction

Myocardial Infarction has left an imprint on the heart in the form of left ventricular remodeling, which is the most important factor in the progression of heart failure and the gaining or losing of long-term cardiovascular prognosis. Traditional risk assessment has a narrow vision on metabolic factors which are most influential in the process of cardiac repair after the event. The cardiometabolic index, a composite of central adiposity along with dyslipidemia, is being recognized as a very easy and simple to use marker that reflects the metabolic stress situation. Observational studies have reported that increased cardiometabolic index is associated with unfavorable left ventricular structural changes such as concentric remodeling and hypertrophy along with decreased diastolic function indicating its use in predicting post-myocardial infarction outcomes. However, the majority of the data available so far come from studies of the general population rather than myocardial infarction-specific groups; yet the reasoning behind the mechanistic pathway is strong enough to support its presence in the post-infarction context where it provides a biologically plausible link between metabolic dysregulation and unfavorable changes in ventricle remodeling. This review presents the current evidence regarding cardiometabolic index and left ventricular remodeling, discusses its role in risk stratification and recognizes the lack of research in this regard. In order to prove cardiometabolic index as a predictor to assess its application in directing personalized interventions aimed at enhancing myocardial recovery, and to increase the associated life span of patients with heart problems, future clinical trials focusing on post-myocardial infarction patients are absolutely necessary.