Publication:

Uric acid as an important biomarker in hypertensive disorders in pregnancy

Background Hypertension in pregnancy is a global problem and complicates approximately 10-17% of pregnancies. The incidence of PIH in India ranges from 5% to 15%. Uric acid is a marker of oxidative stress, tissue injury and renal dysfunction and therefore might be helpful in the prediction of complications of PE. Literature on serum uric acid as a predictor of complications of PE is conflicting. The present is intended to study uric acid as an important biomarker in hypertension in pregnancy.

Methods This was prospective observational analytical case control study of 180 individuals done at JSS Hospital, Mysore, India from January 2015 to July 2016.

Results A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy           (p 6.0mg/dl shows 100% maternal deaths, 79.4% with eclampsia and 71.9% with preterm delivery.

Conclusions A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy. Hyperuricemia in patients with hypertensive disorders of pregnancy is a strong risk factor for several maternal and perinatal complications.