Publication:

Laparoscopic versus open cholecystectomy

Background Laparoscopic cholecystectomy has promptly emerged as a popular alternative to traditional open laparotomy and cholecystectomy. The Objective of the current meta-analysis is to evaluate the effect of Laparoscopic versus open cholecystectomy.

Methods We conducted this meta-analysis using a comprehensive search of Cochrane database of systematic reviews, PubMed, Medline, EMBASE, and Cochrane central register of controlled trials till 15 March 2018 for studies that evaluated laparoscopic versus open cholecystectomy.

Results Eleven studies have been included with a total of 80691 patients: 41485 in the laparoscopic and 39206 into the open cholecystectomy groups. Odds ratios were regularly on the side of laparoscopic operation, in terms of respiratory complications (OR=0.32, 95%CI: 0.34-2.64, p<0.0001), mortality (OR=0.19, 95%CI: 0.08-1.05, p<0.0001), and morbidity (OR=0.31, 95%CI: 0.11-0.45, p<0.0001).

Conclusions Using laparoscopic cholecystectomy decreased morbidity, mortality, and respiratory complications rates. Large-scale and long-term randomized controlled trials in various populations must be carried out in future studies to deliver more significant evidence.