Publication:

A comparative study on the fasting and postprandial lipid abnormalities in type 2 diabetes mellitus in tertiary care teaching hospital of southern Rajasthan, India

Background The worldwide prevalence of diabetes mellitus has risen dramatically. Based on current trends, the International Diabetes Federation projects that 438 million individuals will have diabetes by the year 2030.Type 2 diabetes is characterized by insulin resistance which is associated with hypertension, dyslipidemia, micro and macro vascular disease.

Methods This study was institutional based Case Control comparative study carried out on 200 type 2 diabetes patients and on 200 healthy controls   at tertiary care teaching hospital in Jhalawar, Rajasthan.  Non-probability purposive sampling technique was used followed by interview of 400 participants.

Results In final analysis, Diabetes subjects were middle aged (mean age 43.2±7.48 years) with a mean BMI of 26.9±5.46 kg/m2, matched with controls. Among diabetes patients 152 has positive family history for diabetes. The fasting and postprandial lipid profile were increased in the type 2 DM subjects as compared to controls and among the type 2 DM patients, the postprandial lipid parameters were increased as compared to the fasting level.

Conclusions Both fasting and post prandial lipid abnormalities seen in type 2 diabetes but the post- prandial lipid profile was altered when compare to fasting lipid levels. Lifestyle modifications along with diet and proper lipid lowering drugs are helpful in diabetic individuals with lipid abnormalities.