Publication:

Effects of estrogens and progestagens on the primary variables of haemostasis

Background The present study aims at determining the effect of two combined oral contraceptives on the primary variables of haemostasis in a group of healthy Albanian women.

Methods In this study were included, 49 women between the ages of 24 and 51 years, twenty nine of them taking ethinylestradiol 30 μg and gestodene 75 μg and twenty of them taking ethinylestradiol 30 μg and levonorgestrel 75 μg for 1-2 months. The subjects had no history of thromboembolic disease. Plasma was used for measuring levels of PT, fibrinogen, factors V and VIII, before and after pill use. Collected data were analyzed using SPSS 20 software.

Results Comparison of values of the parameters before and after treatment showed that concentrations of fibrinogen and factor VIII were significantly increased following treatment (p 0.05).

Conclusions The results show that changes in the haemostatic primary variables after combined oral contraceptive administration are significant which might increase the risk for thrombotic situations.