Publication:

Barriers to medication adherence in self-care management of systemic lupus erythematosus patients: a systematic review

Aim of the study was to explore stakeholder viewpoints on factors impending compliance to medication among individuals with systemic lupus erythematosus (SLE). An extensive search of literature was carried out in PubMed, Embase, and Scopus databases extending from January 2000 to January 2026. The review encompassed all qualitative, peer-reviewed articles on obstacles to drug compliance, published in English language. Two individual reviewers evaluated study quality using the critical appraisal skills programme (CASP) qualitative checklist. Enhancing transparency in reporting the synthesis of qualitative research (ENTREQ) guidelines was used to synthesize the qualitative information. A total of eleven studies were selected. Prominent patient level barriers encompassed insufficient knowledge of the disease condition, risks of non-compliance, forgetfulness, inadequate social support, and suboptimal health teaching. Challenges associated to the healthcare resources, includes availability, cost, and suitability, which were noted in many articles. Proposed solution in reviewed articles to combat these included forming support networks, using electronic alerts, physical therapy, and specialized elderly care units at community health centres, along with cultural contextual approaches to patient support. Customized strategies focused on individual needs should be created to enhance management in SLE cases.