Publication:

Relationship between Helicobacter pylori infection and pre-eclampsia among pregnant women in Ardabil

Background Studies have shown that certain infections can increase the risk of pre-eclampsia which one of the common infections among pregnant women was H. pylori with prevalence rate of 60-70% in developing countries. The aim of this study was to investigate the association between H. pylori infection and pre-eclampsia among pregnant women.

Methods Blood and stool samples were taken from 108 women with pre-eclampsia and 108 healthy pregnant women. Blood samples analyzed by ELISA for specific antibodies against H. pylori cytotoxin associated gene A (Cag A) antigen and stool samples were studied in terms of the presence of H. pylori Cag A antigen. Collected data were analyzed using statistical methods in SPSS.20.

Results 30 cases (27.8%) of pre-eclampsia women and 34 (31.5%) of healthy women were sero-positive for Cag A antibodies that was not statistically significant difference. Whereas, 67 cases (62.4%) in the case group and 48 cases (44.4%) in the control group had Cag A antigen in stool samples that was statistically significant difference.

Conclusions Results showed that, based on detection of H. pylori antigen in stool samples, frequency of active H. pylori in women with pre-eclampsia was 1.8 times higher than the healthy women.