Publication:

Fluticasone furoate verses fluticasone propionate: a comparative study by assessment of nasal mucociliary clearance time on patients with allergic rhinitis

Background Allergic diseases in India have been on an uprising trend. 3.5% of the population in INDIA is suffering from Allergic Rhinitis. This study aims to compare the effectiveness of two commonly used intranasal steroids- Fluticasone Furoate (FF) and Fluticasone Propionate (FP) using the nasal mucociliary clearance time (NMCT).

Methods We conducted a prospective study on 70 patients. 35 each on FF and FP. Pretreatment and Post treatment Nasal was assessed by Saccharin Test. Patients were then put on either FF or FP for a period of one month.

Results Average improvement of NMCT post treatment with steroids sprays is 2-3 minutes.(Average Pretreatment time is 17.92 and Average Post treatment time 15.55 minutes).

Conclusion Both drugs are equally efficacious and well tolerated by the patients. Compliance of Fluticasone Furoate was better because of its once daily dosage. Disadvantages of FP are its twice daily dosage and after taste.