Publication:

Our experience of 30 cases of mucormycosis of nose and paranasal sinuses

Background Mucormycosis is life threatening fungal infection that occurs in immunocompromised patient. These infections are becoming increasingly common in yet survival remains very poor a great understanding of the pathogenesis of the disease may lead to future therapies.

Methods In present study we have made an attempt to evaluate a standard method of management of mucormycosis of nose and para nasal sinuses. Total 30 cases of mucormycosis of nose and Para nasal sinuses were studied JIIUS IIMSR Warudi, Badnapur, Jalna a tertiary center from June 2014 to June 2017 thoroughly on the basis of clinical behavior, histopathological report and radiological investigation, we have tried to formulate a standard method of treatment in the form of medical and surgical debridement or combination in order to achieve the best possible results.

Results In this study male patient were 18 (50%) cases and female were 12 (40%). Most common predisposing factor was diabetes mellitus in 24 (80%) cases and other factors were tuberculosis 4 (13.33) and chronic renal failure 5 (16.66).Most commonly presented age group was 4th decade to 5th decade 11 (36.66) and 8 (26.66%) respectively. Most common symptom was nasal obstruction and sign was maxillary swelling 21 (70%). Most common radiological finding was cloudiness of sinuses 27 (90%) least common finding was intracranial extension 6 (20%). Most common used treatment modalities was amphotericin B24 (80%) and least used was surgical debridement by FESS 16 (53%).

Conclusions In the management of mucormycosis and its different pathological forms and most aggressive form like rhino cerebral mucormycosis prompt diagnosis based on clinical examination, reversal of predisposing condition and aggressive surgical debridement along with medical treatment remain corner stone of the therapy for this deadly disease.