Original Research ArticleInternational Journal of Otorhinolaryngology and Head and Neck Surgery
Publication: The role of worst pattern of invasion in the prognosis of oral cavity malignancies
Int J Otorhinolaryngol Head Neck Surg. 2025;11(2):101-109.DOI10.18203/issn.2454-5929.ijohns20250787
Abstract
Background Our study aimed to assess the significance of worst pattern of invasion (WPOI) and its effect on survival in oral cavity squamous cell carcinoma (OCSCC).
Methods This is a retrospective study of patients with OCSCC who underwent surgery. Univariate and bivariate analysis were used to analyze the association between WPOI and demographics, tumor characteristics and treatment. The association of WPOI with overall survival was evaluated.
Results The 3-year OS was 77% for WPOI ≤4 and 70% for WPOI 5 (p=0.5). In the tongue subsite, the 3-year OS was 81% for WPOI ≤4 and 57% for WPOI 5 (p=0.08). WPOI-5 showed significant association with perineural invasion (p<0.01), lymphovascular invasion (p<0.01), lymph node involvement (p<0.03), and higher depth of invasion (p<0.01).
Conclusion WPOI-5 may be considered a prognostic factor in deciding treatment in the post-surgical setting, and my become a mandatory parameter in pathology synoptic reports in the future.
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Affiliations
- Department of Surgery, Division of Otolaryngology, Beth Israel Medical Center, Boston, MA, USA
- Department of Otolaryngology-Head and Neck Surgery-McAlester Regional Health Center, McAlester, USA
- Department of Pathology, Beth Israel Medical Center, Boston, MA, USA
- Department of Surgery, Beth Israel Deaconess Medical Center, Boston, USA