Publication:

Effect of intralesional measles mumps rubella immunotherapy in cutaneous viral warts

Background Viral warts are benign proliferation of the skin and mucosa caused by various strains of double stranded DNA human papilloma virus (HPV). MMR immunotherapy of warts is a novel, simple, cost-effective procedure which treats wart by stimulation of non-specific cell mediated immune response to clear HPV virus from the skin. A study to evaluate the role of intralesional measles mumps rubella (MMR) immunotherapy in cutaneous viral warts.

Methods Total 22 patients of both sexes were included in the study. Intralesional MMR 1 unit (0.1 ml) was injected into the largest wart at 2 weeks interval for a maximum of six treatments. Maximum dose of immunotherapy was 0.5 ml for one session and follow up was kept for 3 months duration.

Results Out of 22, 20 patients completed the treatment, 12 patients (60%) shows complete response, 5 patients (25%) shows partial response and 3 patients (15%) shows no response.

Conclusions Intralesional measles mumps rubella (MMR) immunotherapy is an easy, simple, minimally invasive and relatively painless technique, which helps in induction of an adequate immune response leading to resolution of warts.