Case ReportInternational Journal of Research in Dermatology

Publication:
Langerhans cell histiocytosis in an infant: a case report from North-East India

Int J Res Dermatol. 2020;6(6):792-794.DOI10.18203/issn.2455-4529.IntJResDermatol20204569

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Abstract

Langerhans cell histiocytosis (LCH) is a rare disorder of reticuloendothelial system characterized by uncontrolled proliferation and accumulation of CD1a and CD207 dendritic cells (DCs). 3-4 cases per million occur annually in children under 15 years of age, with a male:female ratio of 2:1 and peak incidence in infants aged 1 to 2 years. Report a case of LCH in a month-old female infant with skin lesions for 2-3 weeks. Skin biopsy was suggestive of LCH and it was confirmed with immunohistochemistry markers that were positive for S100, CD1A and negative for CD68.

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Affiliations

  1. Department of Dermatology, Venereology and Leprology, Regional Institute of Medical Sciences, Imphal, Manipur, India

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