Publication:

Evaluating the non-comedogenic profile of Venusia Sun Unseen: a prospective, double-blind, randomized and controlled study

Background The comedogenic potential of topical sunscreens is an important consideration for both skin safety and long-term adherence to photoprotective regimens. This study aimed to evaluate the comedogenicity of Venusia Sun Unseen sunscreen under occluded conditions, compared with positive and negative controls.

Methods A prospective, randomized, double-blind, positive- and negative-controlled, two-cohort parallel-group study was conducted involving 30 healthy adults aged 18 to 55 years with prominent follicular orifices on the upper back. The test sunscreen (Venusia Sun Unseen) was evaluated against coconut oil as the positive (comedogenic) control, and glycerine as the negative (non-comedogenic) control. Products were applied under occlusive patch chambers on three designated sites on the upper back. Follicular biopsies were obtained before and after 12 alternate-day applications over a 4-week period. Microcomedones were graded on a four-point scale using light microscopy. Statistical comparisons were performed using the Mann–Whitney U test.

Results The method was validated as the positive control showed significantly higher mean comedone grades (2.07±0.84) than the negative control (0.76±0.58; p=0.001). The test product, Venusia Sun Unseen, demonstrated a significantly lower mean comedone grade (0.86±0.95) compared to the positive control (p=0.001), indicating non-comedogenicity. No adverse events related to the test or control products were reported.

Conclusions Venusia Sun Unseen sunscreen is non-comedogenic and safe when applied topically under occluded conditions.