Publication:

Correlation of newer hematological parameters and IL-17A with severity of psoriasis in obese and non-obese patients

Background Psoriasis is a chronic immune-mediated inflammatory disorder associated with obesity and metabolic dysfunction. Interleukin-17A (IL-17A) and newer haematological indices are emerging as markers of systemic inflammation.

Methods This analytical cross-sectional study included 46 psoriasis patients categorized into obese and non-obese groups based on BMI. Hematological parameters, NLR, PLR, and reticulocyte indices were analyzed, and serum IL-17A levels were measured using ELISA. Disease severity was assessed using PASI and CPSS. Statistical analysis was performed using Welch’s t-test and Pearson’s correlation.

Results Obese patients showed higher PASI, CPSS, IL-17A, and ESR levels, though differences were not statistically significant. IL-17A showed a strong positive correlation with PASI in obese patients (r=0.791, p<0.001) and a significant correlation with ESR (r=0.341, p=0.02). ESR showed significant negative correlations with RBC indices. In non-obese patients, IL-17A correlated negatively with reticulocyte indices.

Conclusions IL-17A and hematological inflammatory markers are significantly associated with psoriasis severity. IL-17A may serve as a useful adjunctive biomarker for assessing systemic inflammation in psoriasis.