Publication:

Age at menarche as a predictor of diminished ovarian reserve: a new approach

Background Objective of current study was to investigate whether age at menarche is associated with Functional Ovarian Reserve (FOR) later in life.

Methods Design: Retrospective cohort study.

Setting Gayatri Hospital, Allahabad, Uttar Pradesh, India. Patient(s): One hundred fifty one. Intervention(s): None.

Results The mean age of the patients was 38.9 ± 4.9 years, and their mean level of AMH was 1.4 ± 2.0 ng/ml and of FSH was 10.7 ± 6.1 mIU/ml. Their current age-specific Diminished Functional Ovarian Reserve (DFOR) was statistically significantly associated with early menarche, defined as age 75th percentile).

Conclusions The study demonstrates a statistically significant impact of menarche on DFOR risk later in life among infertile women. The occurrence of menarche may relate to follicular pool size and/or speed of follicle recruitment, which in turn, is predictive of occurrence of DFOR later in life.