Publication:

Antibiotic sensitivity and resistance pattern for neonatal sepsis in Klebsiella and Pseudomonas isolated pathogens in neonatal intensive care unit at tertiary care hospital

Background Neonatal sepsis being one of the major causes for mortality and morbidity in the neonatal intensive care unit (NICU), inadvertent use of antibiotics has led to the emergence of multidrug resistant.

Methods This cross sectional study was conducted between May 2015 to July 2015 in NICU at BTGH. 3 months lab reports were analysed for growth and sensitivity and resistance pattern of commonly used antibiotics.

Results Among 75 cases sent for lab investigation, 58 blood cultures were positive for sepsis and showed growth on culture plate of which 13 (22.4%) were positive for pseudomonas and 19 (32.7%) positive for klebsiella. Meropenem 13 (100%) Piperacillin+TZ and Ceftazidime both 11 (84.6%) were highly sensitive for pseudomonas while Meropenem 18 (94.7%) and Imipenem 12 (63.15%) were highly sensitive for klebsiella. Amoxicillin showed highest resistance for both the pathogens.

Conclusions The results obtained from this study done to evaluate the pattern of antibiotic sensitivity and resistance for neonatal sepsis in klebsiella and pseudomonas isolated pathogens showed that Meropenem as highly sensitive antibiotic and Amoxicillin as highly resistant antibiotic, hence they must be judiciously used to minimize the morbidity and mortality and also to reduce the emergence of multidrug resistant organisms in NICU.