Publication:

Effect of sildenafil on IUGR

Background IUGR is one of the major culprit of perinatal mortality and morbidity in India, with reported incidence of 21-28%. Objective of present study is to investigate the effect of sildenafil on pregnancies complicated with IUGR and to see its effect on fetal outcome.

Methods This was a case control study conducted after clearance of Ethical Committee of the Institute from July 2014 to July 2016 in Department of Obstetrics and Gynecology of Dr. B.R.A.M. Hospital, Raipur [C.G.]. All women with pregnancies complicated with IUGR were identified and included in study. According to treatment with Sildenafil women were divided in two groups. Both groups were followed up till delivery and their outcome including birth weight, AC and complications related to IUGR were compared.

Results IUGR was found to be more prevalent in primi gravidas and women of lower socioeconomic and educational status with low BMI.  We found Hypertension in pregnancy as significant causative factor precipitating the IUGR [68%]. In sildenafil treated group significant 63% mothers had baby with birth weight >10 percentile whereas in sildenafil non treated group only 20% had > 10 percentile birth weight. The mean birth weight of Sildenafil treated group was 2594gm whereas in non-treated group it was 2200gm.  In our study, we observed improved AC in 70% whereas in control group improvement was only in 34% which was significant.

Conclusions Sildenafil was found to improves birth weight, abdominal circumference, and reduce the complications related to IUGR.