Publication:

Effect of hormone replacement therapy on biochemical parameters in post-menopausal women

Background In females, menopause is a loss of natural events that marks the end of the reproductive years. Menopause its associated complications can be managed by hormone replacement therapy (HRT). This study hypothesized to evaluate the effect of hormone replacement therapy on clinico biochemical levels in postmenopausal women.

Methods A total one hundred postmenopausal females were considered. Based on medication administered patients were divided in to five groups i.e. Premarin group, Ovral-L group, Evalon group, Transdermal E2 Gel group and Control group with oral calcium placebo therapy. A complete Haemogram, ECG, Urine examination, lipid profile were investigated.

Results Most common clinical symptoms is vasomotor/psychological (45% in all groups) related followed by urogenital/psychological symptoms (22% in all groups). The mean lipid lipoproteins before therapy, after 2 months and 6 months follow up showed significant change in all the groups.

Conclusions HRT can be a safe method to manage urogenital complication and vasomotor symptoms in postmenopausal women. It has a notable impact on the lipid profile and lipoproteins which helps to reduce the chances to get associated health complications.