Publication:

Effectiveness of Laparoscopic Ovarian Drilling (LOD) on restoration of menstrual cycles, ovulation and pregnancy in clomiphene citrate resistant women with PCOS

Background Anovulatory infertility is present in 75% of patients with polycystic ovarian syndrome (PCOS), in addition to oligomenorrhoea and signs and symptoms of hyperandrogenism. This study was performed to evaluate the role of laparoscopic ovarian drilling (LOD) on ovulation, restoring menstrual cycles and pregnancy in clomiphene resistant women with PCOS.

Methods This prospective cohort study included 50 women who were diagnosed with PCOS and anovulatory infertility. These patients had already tried Clomiphene citrate for conception and did not ovulate, underwent LOD between 1st September 2009 until February 2011 in the Department of Gynecology and Obstetrics, at the Panna Dhay Mahila Chikitasalya, Udaipur. The major outcome measures include spontaneous ovulation, menstrual regularity after LOD and pregnancy rates.

Results Among 50 patients 33 (66%) started to menstruate regularly and 60% ovulated spontaneously, of them 24 (48%) conceived.

Conclusions Women with PCOS respond favourably to LOD.