Publication:

“Free radical induced oxidative stress” (frios) parameters: key to reduce feto-maternal mortality in high risk pregnancies

Background ROS plays role during pregnancy and normal parturition and in recurrent pregnancy loss, initiation of preterm labor, anaemia, preeclampsia, eclampsia, Intrauterine growth retardation. Elevated oxidative stress is found in term infants with fetal distress and in preterm infants. With this background this study was conducted to evaluate the role of FRIOS (free radical induced oxidative stress) in reducing feto -maternal mortality in high risk pregnancies in District Kanpur.

Methods This prospective study was conducted on pregnant women at high risk attending department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur after taking permission from the institutional ethical committee. Informed consent was obtained from all patients. Investigations were carried out to measure oxidant level of Malonaldialdehyde (MDA) enzyme & to measure anti oxidant Super Oxide Dismutase (SOD) enzyme. Levels of these enzymes were compared between normal & each high risk sub groups separately. SPSS software was used for statistical analysis and suitable tests were applied.

Results The mean value in study group was highest in severely anaemic patients (8.53±1.398 Nmoles/ml of plasma) followed by pre eclamptic & eclamptic patients (8.33±1.355 Nmoles/ml of plasma). The mean levels of in study group was lowest in pre eclamptic & eclamptic patients (0.394±.191 u/mg of protein) followed by pre term patients (0.413±0.141 u/mg of protein). Significant difference between MDA enzyme levels in control group and all sub groups of study group was found.

Conclusions Measurement of Malonaldialdehyde (MDA) & Super Oxide Dismutase (SOD) enzymes at an earlier stage can be a valuable tool for early diagnosis, so that we can timely intervene & improve the maternal outcome.