Publication:

Study of anti-inflammatory activity of omeprazole in complete Freund’s adjuvant induced arthritic rats

Background Rheumatoid arthritis (RA) is a chronic, progressive, and systemic inflammatory disease, characterized by synovial proliferation and joint erosions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used as an important part of therapeutic regime to suppress the pain and inflammation associated with RA. The modern drugs both steroidal and nonsteroidal anti-inflammatory drugs (NSAIDS) and disease modifying antirheumatic drugs (DMARDSs) are used for the amelioration of the symptoms of the disease; however, they offer only temporary relief and also produce adverse effects. This study was done to evaluate anti-inflammatory activity of Omeprazole in CFA induced arthritic rats.

Methods Animals were divided into five groups of six each, group I as control, group II as standard whereas groups III, IV and V as test groups (three doses). Anti-inflammatory effect of group II Diclofenac sodium (10 mg/kg orally) and group III, IV and V received Omeprazole (10mg/kg, 20mg/kg, and 30mg/kg bodyweight orally respectively) was evaluated in adult albino rats by Plethysmometer on 7th, 14th and 21st day post adjuvant injection.

Results Group 3 produced a significant suppression of paw volume with P value (<0.05) and Group 4 produced a very significant suppression with P value (<0.001) compared to other groups.

Conclusions Omeprazole, a PPI, has anti-inflammatory activity.