Publication:

Evaluation of anti-inflammatory activity of ethanolic extract of Cananga odorata Lam in experimental animals

Background The current study evaluates the anti-inflammatory activity of ethanolic extract of Cananga odorata Lam (EECO) in experimental animals.

Methods Acute toxicity test was done following OECD guidelines. Carrageenan induced paw edema method in Wistar Albino rats were used in this study. Aspirin in the dose of 300 mg/kg was used as the standard drug and three doses of EECO (100 mg/kg, 200 mg/kg and 400 mg/kg b.w. p.o) were used as the test drug. The results were measured at 1st hr, 3rd hr and 5th hr after carrageenan injection.

Results EECO in the doses of 100 mg/kg, 200 mg/kg and 400 mg/kg showed highly significant anti-inflammatory activity (p<0.001) (p<0.001) (p<0.001) at 3rd hr and (p<0.001) (p<0.001) (p<0.001) 5th hr, respectively. In doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg of EECO showed the percentage of inhibition of 62.9% which is more than the standard drug aspirin, which showed 60.14% inhibition.

Conclusion EECO has significant anti-inflammatory activity.