Publication:

Evaluation of nephroprotective and nephrocurative activity of Aegle marmelos on albino rats using experimental model

Background Renal diseases are common now days because of multiple nephrotoxic drugs use like aminoglycosides, analgesic etc. Many diseases like Diabetes and Hypertension also contributing to renal diseases. One of the mechanisms for nephrotoxicity is production of free radicals. The phytochemicals obtained from some plants are claimed to be useful in prevention of nephrotoxicity. One of the good sources of these phytochemicals is leaves of Aegle marmelos (Bael) which has antioxidant property that can be useful in nephroprotection. Hence this study was designed to investigate the nephroprotective as well as nephrocurative potential of Aegle marmelos.

Methods Study was done on albino rats at LLRM Medical College as per CPCSEA guidelines after obtaining permission from IAEC. Nephrotoxicity was induced using injection gentamicin(40mg/kg). The nephroprotective and nephrocurative effect was quantified using serum markers (BUN, Serum creatinine) and histopathological changes. Statistical analysis was done using ANOVA followed by post hoc dunnet’s test.

Results When compared with gentamicin induced nephrotoxicity, rats those who received aqueous extract of Aegle marmelos leaves showed significant (p<.001) reduction in nephrotoxicity.

Conclusions It can be concluded from this study that leaves of Aegle marmelos possess siginificant nephroprotective activity.