Publication:

The role of parenteral tranexamic acid in reducing blood loss in normal labour

Background Obstetric blood loss can be reduced by using anti-fibrinolytic agents.

Methods 200 patients undergoing normal vaginal delivery and fulfilling the inclusion criteria were recruited for the study. In each patient pre-delivery and post-delivery vital parameters and blood indices were noted. The study group received injection tranexamic acid while the control group received only placebo injection in addition to the active management of third stage of labour. The amount of blood loss immediately after delivery and 2 hours after delivery were measured using blood drape and pre-weighed pads respectively.

Results There was a significant increase in the pulse rate and decrease in blood pressure in the control group. The post-delivery hemoglobin and hematocrit were significantly reduced in the control group. The blood loss at the end of 2 hours was more in the control group. The usage of additional uterotonics, need for blood transfusion, and duration of hospital stay was also increased in the control group.

Conclusions Tranexamic acid injection, an antifibrinolytic agent given intravenously after the delivery of the baby appears to reduce blood loss during normal vaginal delivery effectively.